The exact cause of the development of rheumatoid arthritis has not been definitively established. It is believed that the disease occurs due to a combination of several factors: impaired functioning of the immune system, hereditary predisposition and the influence of external factors. As a result, the immune system mistakenly attacks the tissues of its own joints, because of which chronic inflammation occurs.
Factors that may increase the risk of developing the disease include:
- hereditary predisposition to autoimmune diseases;
- smoking;
- hormonal changes;
- previous viral or bacterial infections;
- prolonged stress;
- excess body weight and some metabolic disorders.
In some patients, the first manifestations may occur gradually: first morning stiffness, pain or swelling in the small joints of the hands or feet appear. Sometimes the inflammatory process is accompanied by general weakness, increased fatigue or enlargement of the lymph nodes — lymphadenopathy.
According to American College of Rheumatology, the risk of developing rheumatoid arthritis may be higher in people with hereditary predisposition, as well as under the influence of external factors, in particular smoking. That is why during the consultation the doctor clarifies the patient’s family history, lifestyle and concomitant diseases.