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Pipelle Biopsy

Pipeline biopsy

Endometrial biopsy is a diagnostic procedure that involves taking a sample of the endometrial tissue (the lining of the uterus) for laboratory analysis. In the past, this was performed by scraping with a curette, a method that is quite traumatic and painful and therefore requires general anesthesia.

Pipelle biopsy is a minimally invasive method that allows for the collection of an endometrial sample quickly, safely, and painlessly. The material is collected using a silicone probe with a vacuum system. The probe is only 3 mm in diameter, so it is inserted through the vagina without the need for cervical dilation. The patient experiences no pain and does not require anesthesia. The procedure is carried out in a gynecological office, takes just a few minutes, and allows the patient to leave the clinic immediately afterward.

The sample obtained via pipelle biopsy is sent to the laboratory for analysis. The results allow for an accurate diagnosis and selection of the most effective treatment.

At Oxford Medical, pipelle biopsy is performed by highly qualified gynecologists with many years of experience. We use high-quality materials and expert-class equipment, ensuring a gentle procedure and high accuracy of test results.

When is a pipelle biopsy prescribed?

Pipelle biopsy is prescribed to diagnose various gynecological diseases, as well as to assess the effectiveness of treatment.

The main indications include:

  • Suspicion of endometrial hyperplasia or cancer;

  • Detection of polyps and other neoplasms;

  • Endometriosis;

  • Chronic endometritis;

  • Abnormal uterine bleeding, including during menopause;

  • Infertility and preparation for IVF;

  • Evaluation of therapy effectiveness.

How is a pipelle biopsy performed?

The procedure is minimally invasive and performed in a regular gynecological office. It takes just a few minutes and does not require anesthesia.

The patient lies on a gynecological chair. The doctor inserts a speculum, then introduces a sterile pipelle (a thin flexible tube, 3 mm in diameter) through the cervix into the uterine cavity. The doctor then pulls out the plunger of the pipelle, creating negative pressure and enabling aspiration (suction) of the endometrial tissue sample. After that, the pipelle is removed, and the collected sample is placed in a special container and sent to the laboratory for analysis.

Laboratory testing of the biopsy sample takes up to 10–14 days. Afterward, the patient is scheduled for a follow-up appointment with a gynecologist.

The tests can identify inflammatory processes, atypical cells, hyperplastic, atrophic, or fibrous changes in the endometrium.

Advantages of pipelle biopsy at Oxford Medical

Providing patients with high-quality medical care using advanced diagnostic and treatment methods is the main priority of the Oxford Medical team. Our clinic employs only experienced and highly qualified doctors, and features new expert-level equipment.

The advantages of pipelle biopsy at Oxford Medical include:

  • The procedure is performed by experienced obstetrician-gynecologists;

  • The use of high-quality materials ensures a painless and safe procedure;

  • The highest accuracy of laboratory test results;

  • The ability to undergo additional diagnostics and treatment for a wide range of diseases at the same clinic;

  • Comfortable conditions and a loyalty program for regular patients.

How to prepare for an endometrial pipelle biopsy

A few days before the pipelle biopsy, women are advised to avoid sexual intercourse, not to use tampons, and to refrain from douching. Additionally, if the patient has a low pain threshold, the doctor may recommend taking a pain reliever one hour before the procedure.

Pipelle biopsy is performed on different days of the menstrual cycle, depending on the goal of the examination. In particular, endometrial sampling may be done:

  • In the early days of the cycle when endometrial hyperplasia is suspected;

  • In the second phase if IVF is planned;

  • At the end of the cycle in cases of hormonal disorders;

  • Regardless of the cycle in postmenopausal women with uterine bleeding or suspected cancer.

Since biopsy is an additional diagnostic method, the patient may first be prescribed pelvic ultrasound, smear and scraping tests for infections, a Pap test, colposcopy, and other examinations if indicated.

Recovery after pipelle biopsy

Since pipelle biopsy is a non-traumatic procedure, the patient can leave the clinic immediately after it is completed.

For a few days, there may be cramping pain in the lower abdomen and light spotting. Until these symptoms subside, it is recommended not to use tampons and to abstain from sexual intercourse.

In case of severe pain, bleeding, fever, or other complaints, it is necessary to contact a doctor.

Pipelle endometrial biopsy: price at Oxford Medical

You can check the price of a pipelle biopsy here. Keep in mind that the procedure is prescribed for histological, cytological, or other types of analysis of the endometrial sample. Therefore, the final cost of the examination may vary. A gynecologist will give more precise information during the initial consultation. Book an appointment at a time convenient for you — call us or leave a request on the website.

FAQ

Pipelle biopsy: what is it?

Pipelle biopsy is a minimally invasive method of collecting an endometrial sample (uterine lining) using a thin flexible tube with a vacuum system. The procedure takes just a few minutes and does not require anesthesia. The collected sample is sent for analysis, which allows the diagnosis of a wide range of gynecological conditions.

Pipelle biopsy: what does it show?

Pipelle biopsy allows for the evaluation of the condition of the endometrium. The results can reveal inflammatory processes, hyperplasia, polyps, cancerous and precancerous changes. The examination also helps diagnose causes of abnormal uterine bleeding, infertility, and confirm or rule out various endometrial pathologies.

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Advantages of gynecology at Oxford Medical in Kyiv

Experienced gynecologists. Doctors with extensive clinical experience who regularly complete professional development courses.

Modern diagnostics. Ultrasound, colposcopy, hysteroscopy, laboratory tests.

Comprehensive approach to women’s health. Treatment tailored to age and comorbid conditions.

Surgical capabilities. From minimally invasive to open surgeries performed in a modern surgical facility.

Convenient clinic locations. Departments are available throughout Kyiv — on both the right and left banks.

Comfort at every stage. Attentive care, modern facilities, and a welcoming atmosphere.

Our doctors

Manovytska Oksana Viktorivna
4.98
rating (45)
26+
Years of experience
Online consultation
Obstetrician-gynecologist of the highest category. Specialist in aesthetic gynecology, ultrasound doctor
26+ Years of experience
Consultation 1100
Kyiv, Hlybochytska St., 40x
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Kashatyn Zhanna Aleksandrovna
4.9
rating (20)
6+
Years of experience
Online consultation
Obstetrician-gynecologist, ultrasound doctor
Specialist in aesthetic gynecology.
6+ Years of experience
Consultation 1100
Kyiv, Hlybochytska St., 40x
Kyiv, Vasyl Lypkivskoho St., 38
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Kvashenko Valentina Pavlivna - gynecologist at the Oxford Medical private clinic in Kyiv
5
rating (2)
54+
Years of experience
Obstetrician-gynecologist of the highest category, Professor, Doctor of Medical Sciences.
54+ Years of experience
Consultation 1989
m. Kyiv, Parkovo-Syretska St., 7A
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Demura Olena Valeriivna
4.97
rating (31)
20+
Years of experience
Online consultation
Obstetrician-gynecologist of the Highest Category, Specialist in Aesthetic Gynecology
20+ Years of experience
Consultation 1100
Kyiv, 9 Ivana Kramskoho Street
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Reviews
Яна 06.07.2026
Карина Олегівна чудова спеціалістка, яка чітко знає свою справу. Візит пройшов дуже комфортно, в спокійній атмосфері. Лікарка уважно вислухала всі запитання, надала чіткі, зрозумілі рекомендації без зайвих призначень. Обов'язково звертатимуся ще та рекомендую як надійного спеціаліста.
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Тетяна 05.07.2026
Хочу щиро подякувати Мельник Вікторії Вікторівні! Це дуже кваліфікований, уважний і відповідальний лікар. Перебуваю в неї на лікуванні з перших днів. Саме Вікторія Вікторівна вчасно виявила мою проблему, призначила правильне лікування, і завдяки цьому ми успішно все подолали. Після пройденого лікування мені вдалося завагітніти. Зараз веду в неї вагітність, і це було найкращим рішенням. Вікторія Вікторівна завжди на зв’язку, уважно вислухає, відповість на всі запитання, підтримає та заспокоїть. Це лікар, який щиро переживає за своїх пацієнтів і ставиться до кожного з великою турботою. Від щирого серця рекомендую!
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